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KMID : 1035620160040030212
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Allergy Asthma & Respiratory Disease
2016 Volume.4 No. 3 p.212 ~ p.216
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Rapid desensitization to isoniazid and rifampin in an adolescent with active pulmonary tuberculosis
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Lee Hei-Rim
Kim Min-Sun
Yang Hea-Kyoung
Kim Min-Ji
Lee Ji-Young
Kim Jong-Min
Kang Ji-Man
Kim Yae-Jean
Ahn Kang-Mo
Kim Ji-Hyun
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Abstract
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Hypersensitivity reactions to antituberculosis medicine are obstacles to the treatment of tuberculosis. However, rapid drug desensitization can secure successful treatment with essential antituberculosis medicines in pediatric patients. A 17-year-old boy with active pulmonary tuberculosis complained of generalized erythematous rashes, pruritus on the 11th day of tuberculosis treatment. He was diagnosed with hypersensitivity reactions to isoniazid and rifampin by the oral provocation test. After desensitization, the patient continued to take antituberculosis treatment with isoniazid, rifampin, pyrazinamide, and ethambutol. We report here a case of successful desensitization in an adolescent with hypersensitivity to isoniazid and rifampin.
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KEYWORD
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Immunologic desensitization, Antitubercular agents, Drug hypersensitivity
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